Endocrine Abstracts

The way to maleness is a long process starting with fertilization when sperm delivers the testis-determining Y chromosome to the oocyte and ending with puberty and the action of testicular hormones. Since Sertoli cells are at the crossroads of the entire process, the analysis of the factors driving their differentiation and function is essential to the global understanding of male sexual development. By using mouse functional genetics, we will show that growth factors of the i...

The adrenal cortex, a pivotal endocrine regulator governing body homeostasis, metabolism, and stress response through steroid hormone synthesis, presents formidable challenges for effective replacement in disorders like adrenal insufficiency and congenital adrenal hyperplasia. The limitations of current hormone replacement strategies stem from the intricate dynamics of hormonal release. This study harnesses insights derived from the analysis of a recently published single-cell...